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James Root

James Root

AstraZeneca, Sweden - Södertälje / Sweden
Medical and Health Sciences / Pharmacology
AD Scientific Index ID: 4454000
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person_outline James Root's MOST POPULAR ARTICLES
1-) In vitro and in vivo characterization of PF‐04418948, a novel, potent and selective prostaglandin EP2 receptor antagonist British journal of pharmacology 164 (7), 1847-1856, 2011
2-) Dipeptidyl peptidase 1 inhibitor AZD7986 induces a sustained, exposure‐dependent reduction in neutrophil elastase activity in healthy subjects Clinical Pharmacology & Therapeutics 104 (6), 1155-1164, 2018
3-) Discovery of second generation reversible covalent DPP1 inhibitors leading to an oxazepane amidoacetonitrile based clinical candidate (AZD7986) Journal of Medicinal Chemistry 59 (20), 9457-9472, 2016
4-) Linking increased airway hydration, ciliary beating, and mucociliary clearance through ENaC inhibition American Journal of Physiology-Lung Cellular and Molecular Physiology 308 (1 …, 2015
5-) Attached stratified mucus separates bacteria from the epithelial cells in COPD lungs JCI insight 3 (17), e120994, 2018